3D Printer HardwareBioinksBioprinting

Tethon 3D launches Bison Bio Printer

The full ecosystem includes the first commercial DLP system for bioprinting, a photoinitiator and a GelMa bioink

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Tethon 3D, a pioneer in technical ceramic and 3D printing materials, is entering the field of bioprinting with the launch of a full bioprinting ecosystem. This innovative suite includes the Bison Bio DLP 3D printer, co-developed with high-speed DLP 3D printer manufacturer Carima, alongside Tethon LAP photoinitiator and Tethon GelMA hydrogel bioink, created in partnership with Cell Bark Innovation. This comprehensive offering marks Tethon’s entrance into the bioprinting revolution.

Tethon3D launches Bison Bio Printer with full ecosystem that includes DLP system for bioprinting, a photoinitiator and a GelMa bioink Bioprinting holds immense promise for redefining the future of medicine and medical research. Imagine replicating intricate tissues and organs, using real cell lines, for groundbreaking research and personalized treatments. Tethon 3D recognizes this potential and is committed to advancing it.

“For over a decade, Tethon 3D has thrived on pushing the boundaries of 3D printing with advanced technical ceramic materials,” said Tethon 3D Co-founder and Nebraska Medicine CEO James Linder, MD. “We are thrilled to leverage our expertise in a new arena – bioprinting – and contribute to advancements in regenerative medicine.”

Tethon 3D’s foray into bioprinting isn’t a random step. The company’s founders, with their medical backgrounds, are deeply committed to propelling advancements in healthcare and biomedical research. This dedication is further amplified by the collaboration with Dr. Hojae Bae, a prominent researcher and Tethon’s bioprinting advisor. Dr. Bae Ph.D, of Konkuk University (Korea), formerly of Harvard Medical School, and Clemson University, is founder of CellBark Innovation, producer of hydrogels.  He has published over 140 research papers on bio-industrial technologies.

“I participated in research that first demonstrated the cell-responsive properties of GelMA in 2010 and in the past decade my efforts have been focused on the optimization of bioprinting platforms to achieve rapid production of high-resolution and complex 3D structures,” adds Dr. Bae. “I am pleased to now collaborate with Tethon to accelerate medical research.”

After the first Bison DLP 3D printer for ceramics was introduced in 2019, Tethon 3D’s Bison Bio is an R&D desktop DLP printer specifically designed for bioprinting. It the first commercial system based on DLP technology. This versatile machine boasts fully adjustable settings, allowing researchers to explore the vast potential of Tethon’s materials and even develop custom bio-materials. Priced competitively at under $20,000, the Bison Bio boasts features optimized for superior cell viability, making it ideal for medical, pharmaceutical, and other scientific laboratories.

GelMA scaffolds fabricated using digital light processing (DLP) 3D printing and cell viability analysis (Unpublished Data). (A) Structure of DLP printing and printed GelMA scaffolds. Scale bar: 8 mm. (a) 4x microscope image of the GelMA scaffold. Scale bar: 500 μm. (b) 4x fluorescence staining of the GelMA scaffold. Cells are stained with an F-actin (red), and nuclei are stained with DAPI (blue). Scale bar: 500 μm. (c) 10x fluorescence staining of the GelMA scaffold. Cells are stained with an F-actin (red), and nuclei are stained with DAPI (blue). Scale bar: 200 μm. (B) Fibroblast cell viability analysis of 3D printed GelMA scaffolds on day 1, day 3, and day 5 using Live/Dead assay. Live cells produce green fluorescence, and dead cells show red fluorescence. Data are shown as means ± SD (n = 3). Data are analyzed by a one-way ANOVA followed by Tukey’s post-hoc test. Scale bar: 500 μm.

Tethon GelMA and LAP bioink come in a convenient powder form, allowing for individual or bundled purchases. Easy-to-follow instructions guide users in mixing the bioink for optimal results. Tethon’s commitment to affordability extends to GelMA, which is concentrated for enhanced cell viability and available in budget-friendly 2-gram quantities.

“We are eager to explore the possibilities of bioprinting and empower researchers to unlock new frontiers in medical discovery, ultimately improving lives,” concludes Trent Allen, Tethon 3D CEO.

The Bison Bio printer and its supporting bioinks are available for purchase now.

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Davide Sher

Since 2002, Davide has built up extensive experience as a technology journalist, market analyst and consultant for the additive manufacturing industry. Born in Milan, Italy, he spent 12 years in the United States, where he completed his studies at SUNY USB. As a journalist covering the tech and videogame industry for over 10 years, he began covering the AM industry in 2013, first as an international journalist and subsequently as a market analyst, focusing on the additive manufacturing industry and relative vertical markets. In 2016 he co-founded London-based VoxelMatters. Today the company publishes the leading news and insights websites VoxelMatters.com and Replicatore.it, as well as VoxelMatters Directory, the largest global directory of companies in the additive manufacturing industry.

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