AM ResearchBioinksBioprintingCosmetics Testing

RPI scientists 3D print hair follicles in lab-grown skin

Potential applications include those in regenerative medicine and drug testing, although engineering skin grafts that grow hair are still several years away

Stay up to date with everything that is happening in the wonderful world of AM via our LinkedIn community.

According to Rensselaer Polytechnic Institute (RPI), a team led by scientists from the university has 3D printed hair follicles in human skin tissue cultured in the lab. This marks the first time researchers have used the technology to generate hair follicles, which play an important role in skin healing and function.

The finding, published in the journal ‘Science Advances’, has potential applications in regenerative medicine and drug testing, though engineering skin grafts that grow hair are still several years away.

“Our work is a proof-of-concept that hair follicle structures can be created in a highly precise, reproducible way using 3D bioprinting. This kind of automated process is needed to make future biomanufacturing of skin possible,” said Pankaj Karande, Ph.D., an associate professor of chemical and biological engineering and a member of Rensselaer’s Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies, who led the study. “The reconstruction of hair follicles using human-derived cells has historically been a challenge. Some studies have shown that if these cells are cultured in a three-dimensional environment, they can potentially originate new hair follicles or hair shafts, and our study builds on this work.”

When it comes to engineering human skin, hair may at first seem superfluous. However, hair follicles are quite important as they produce sweat, helping regulate body temperature, and they contain stem cells that help skin heal. Hair follicles are also an entry point for topical drugs and cosmetics, making them an important part of dermatological testing. However, today, initial safety testing is done on engineered skin tissues that lack hair follicles.

“Right now, contemporary skin models – the engineered structures that mimic human skin – are quite simple. Increasing their complexity by adding hair follicles would give us even more information about how skin interacts with topical products,” said Carolina Catarino, Ph.D., first author of the study, who earned her doctorate at Rensselaer and is now a researcher developing new skin testing methods at Grupo Boticário, a cosmetics company in her home country of Brazil.

“Dr. Karande’s lab is at the forefront of skin tissue engineering. This team has already successfully printed skin with working blood vessels, and this latest research is an exciting next step in developing and testing better treatments for burns and other skin conditions,” said Deepak Vashishth, Ph.D., director of the Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies.

“Dr. Karande’s work is a great example of advances being made by RPI researchers at the interface of engineering and life sciences with impact on human health,” said Shekhar Garde, Ph.D., dean of Rensselaer’s School of Engineering. “Bringing multichannel 3D printing to biological realm is opening exciting opportunities that would have been hard to imagine in the past.”

The researchers created their follicle-bearing skin with 3D printing techniques adapted for printing at the cellular level. The scientists begin by allowing samples of skin and follicle cells to divide and multiply in the lab until there are enough printable cells. Next, the researchers mix each type of cell with proteins and other materials to create the ‘bio-ink’ used in the printer. Using an extremely thin needle to deposit the bio-ink, the printer builds the skin layer by layer, while also creating channels for depositing the hair cells. Over time, the skin cells migrate to these channels surrounding the hair cells – mirroring the follicle structures present in real skin.

Right now, these tissues have a lifespan of two to three weeks, which is not enough time for hair shafts to develop. The RPI research team’s future work aims to extend that period – allowing the hair follicle to mature further and paving the way for their use in drug testing and skin grafts.

Composites AM 2024

746 composites AM companies individually surveyed and studied. Core composites AM market generated over $785 million in 2023. Market expected to grow to $7.8 billion by 2033 at 25.8% CAGR. This new...

Edward Wakefield

Edward is a freelance writer and additive manufacturing enthusiast looking to make AM more accessible and understandable.

Related Articles

Leave a Reply

Your email address will not be published. Required fields are marked *

Back to top button
Close Popup
Privacy Settings saved!
Privacy Settings

When you visit any web site, it may store or retrieve information on your browser, mostly in the form of cookies. Control your personal Cookie Services here.

These cookies are necessary for the website to function and cannot be switched off in our systems.

Technical Cookies
In order to use this website we use the following technically required cookies
  • wordpress_test_cookie
  • wordpress_logged_in_
  • wordpress_sec

Decline all Services
Accept all Services


Join our 12,000+ Professional community and get weekly AM industry insights straight to your inbox. Our editor-curated newsletter equips executives, engineers, and end-users with crucial updates, helping you stay ahead.