3D printed contact lens delivers eye medication
The hydrogel, developed by the University of Waterloo, continuously delivers the drugs it as long as the lens is worn
According to the University of Waterloo, a team of researchers – which spans Waterloo’s Department of Chemistry and its School of Optometry and Vision Science – has created a new type of hydrogel that can deliver drugs to patients with various eye issues when 3D printed onto a contact lens. The silicone-based hydrogel can help control the amount of medication a person would need – continuously delivering it as long as the contact lens is worn.
Using these hydrogel-loaded contact lenses could help physicians reduce pain and the number of times the patient has to apply the drug, as the medication is delivered during normal contact lens wear.
Even though silicone can be tricky to 3D print, this new hydrogel is different because it uses a special type of silicone that easily attracts water and is curable with UV light. After curing, the gel is flexible and durable enough to keep its shape after being stretched and compressed.
“Once we knew the hydrogel had good strength and flexibility, we decided to test its ability to hold and release drugs by using amoxicillin, a commonly prescribed antibiotic for ailments related to the eye,” said Shirley Tang, a University of Waterloo professor in the Department of Chemistry and Associate Dean of Research in the Faculty of Science.
The researchers found that the hydrogel’s macro-porous structure helped regulate the release of amoxicillin over time during lab testing. The hydrogels were also found to be injectable and extrusion printable, meaning they could easily be printed onto a contact lens.
“This concept is much more efficient and easier to comply with than using eye drops, which are often difficult to insert for patients and need frequent administration over the day,” said Lyndon Jones, a Waterloo professor in the School of Optometry and Vision Science and Director of the Centre for Ocular Research & Education.
“After being encapsulated in the gel and stored for a month, the amoxicillin was found to have negligible changes,” said Sayan Ganguly, a post-doctoral researcher in the Department of Chemistry. “Our results showed that this hydrogel is safe for human eyes and can be effectively used in diverse biomedical applications.”
With their recently filed patent, the researchers aim to expand the use of contact lenses for treating eye illnesses.
The paper, titled ‘Injectable and 3D Extrusion Printable Hydrophilic Silicone-Based Hydrogels for Controlled Ocular Delivery of Ophthalmic Drugs’, was recently published in ACS Applied Bio Materials.
